Journal of Medicinal Chemistry
Volume 39, Issue 11 (May 24, 1996)
Copyright © 1996 American Chemical Society

Click [Full Article - PDF] to display or print the full article page image in PDF.

2103-2117

The Enediyne Antibiotics Adrian L. Smith and K. C. Nicolaou [Full Article - PDF]

2118-2122

Discovery of an Orally Active Non-Peptide Fibrinogen Receptor Antagonist Hans Ulrich Stilz, Bernd Jablonka, Melitta Just, Jochen Knolle, Erich Friedrich Paulus, and Gerhard Zoller [Full Article - PDF]

2123-2128

Discovery and Optimization of a Novel Class of Orally Active Nonpeptidic Endothelin-A Receptor Antagonists Hartmut Riechers, Hans-Peter Albrecht, Willi Amberg, Ernst Baumann, Harald Bernard, Hans-Joachim Böhm, Dagmar Klinge, Andreas Kling, Stefan Müller, Manfred Raschack, Liliane Unger, Nigel Walker, and Wolfgang Wernet [Full Article - PDF]

2129-2140

Comparative Molecular Moment Analysis (CoMMA): 3D-QSAR without Molecular Superposition B. D. Silverman and Daniel. E. Platt [Full Article - PDF]

2141-2155

Molecular Structure, Conformational Analysis, and Structure-Activity Studies of Dendrotoxin and Its Homologues Using Molecular Mechanics and Molecular Dynamics Techniques Panchanadam Swaminathan, Meena Hariharan, Ramachandran Murali, and Chandra U. Singh [Full Article - PDF]

2156-2169

Preparation and Structure-Activity Relationship of Novel P1/P1'-Substituted Cyclic Urea-Based Human Immunodeficiency Virus Type-1 Protease Inhibitors David A. Nugiel, Kim Jacobs, Tabitha Worley, Mona Patel, Robert F. Kaltenbach III, Dayton T. Meyer, Prabhakar K. Jadhav, George V. De Lucca, Thomas E. Smyser, Ronald M. Klabe, Lee T. Bacheler, Marlene M. Rayner, and Steven P. Seitz [Full Article - PDF]

2170-2177

Tyrphostins. 5. Potent Inhibitors of Platelet-Derived Growth Factor Receptor Tyrosine Kinase: Structure-Activity Relationships in Quinoxalines, Quinolines, and Indole Tyrphostins Aviv Gazit, Harald App, Gerald McMahon, Jefferey Chen, Alexander Levitzki, and Frank D. Bohmer [Full Article - PDF]

2178-2187

Ureido-Based Peptidomimetic Inhibitors of Herpes Simplex Virus Ribonucleotide Reductase: An Investigation of Inhibitor Bioactive Conformation Neil Moss, Pierre Beaulieu, Jean-Simon Duceppe, Jean-Marie Ferland, Jean Gauthier, Elise Ghiro, Sylvie Goulet, Ingrid Guse, Montse Llinàs-Brunet, Raymond Plante, Louis Plamondon, Dominik Wernic, and Robert Déziel [Full Article - PDF]

2188-2196

Inhibition of DNA Topoisomerase II by Azaelliptitoxins Functionalized in the Variable Substituent Domain Jetze J. Tepe, Jose S. Madalengoitia, Kelli M. Slunt, Karl W. Werbovetz, P. Grant Spoors, and Timothy L. Macdonald [Full Article - PDF]

2197-2206

Diphenylpropionic Acids as New AT1 Selective Angiotensin II Antagonists Carmen Almansa, Luis A. Gómez, Fernando L. Cavalcanti, Alberto F. de Arriba, Ricardo Rodríguez, Elena Carceller, Julián García-Rafanell, and Javier Forn [Full Article - PDF]

2207-2218

Modeling Study on a Hydrolytic Mechanism of Class A -Lactamases Masaji Ishiguro and Seiichi Imajo [Full Article - PDF]

2219-2231

Structure-Activity Studies of 6-(Tetrazolylalkyl)-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 1. Effects of Stereochemistry, Chain Length, and Chain Substitution Paul L. Ornstein, M. Brian Arnold, Nancy K. Allen, Thomas Bleisch, Peter S. Borromeo, Charles W. Lugar, J. David Leander, David Lodge, and Darryle D. Schoepp [Full Article - PDF]

2232-2244

Structure-Activity Studies of 6-Substituted Decahydroisoquinoline-3-carboxylic Acid AMPA Receptor Antagonists. 2. Effects of Distal Acid Bioisosteric Substitution, Absolute Stereochemical Preferences, and in Vivo Activity Paul L. Ornstein, M. Brian Arnold, Nancy K. Allen, Thomas Bleisch, Peter S. Borromeo, Charles W. Lugar, J. David Leander, David Lodge, and Darryle D. Schoepp [Full Article - PDF]

2245-2252

Synthesis and Structure-Activity Relationships of 6-Substituted Androst-4-ene Analogs as Aromatase Inhibitors Mitsuteru Numazawa, Takayuki Kamiyama, Mii Tachibana, and Mariko Oshibe [Full Article - PDF]

2253-2258

Synthesis, Absolute Configuration, and Biological Profile of the Enantiomers of trans-[2-(2,6-Dimethoxyphenoxy)ethyl][(3-p-tolyl-2,3-dihydro-1,4- benzodioxin-2-yl)methyl]amine (Mephendioxan), a Potent Competitive 1A-Adrenoreceptor Antagonist Wilma Quaglia, Maria Pigini, Seyed K. Tayebati, Alessandro Piergentili, Mario Giannella, Amedeo Leonardi, Carlo Taddei, and Carlo Melchiorre [Full Article - PDF]

2259-2269

Synthesis and Pharmacological Characterization of All Sixteen Stereoisomers of 2-(2'-Carboxy-3'-phenylcyclopropyl)glycine. Focus on (2S,1'S,2'S,3'R)-2-(2'-Carboxy-3'-phenylcyclopropyl)glycine, a Novel and Selective Group II Metabotropic Glutamate Receptors Antagonist Roberto Pellicciari, Maura Marinozzi, Benedetto Natalini, Gabriele Costantino, Roberto Luneia, Gianluca Giorgi, Flavio Moroni, and Christian Thomsen [Full Article - PDF]

2270-2276

Synthesis and Physicochemical, Biological, and Pharmacological Properties of New Bile Acids Amidated with Cyclic Amino Acids Aldo Roda, Carolina Cerrè, Anna C. Manetta, Gianfranco Cainelli, Achille Umani-Ronchi, and Mauro Panunzio [Full Article - PDF]

2277-2277

The RBI Handbook of Receptor Classification and Signal Transduction Edited by Keith J. Watling, John W. Kebabian, and John L. Neumeyer. Research Biochemicals International, Natick, MA. 1995. vii + 196 pp. 22.5 × 27.5 cm. ISBN 0-96405548-1-7. $35.00. John Wm. Ferkany [Full Article - PDF]

2277-2278

Benzodiazepine Receptor Inverse Agonists Edited by M. Starter, D. J. Nutt, and R. G. Lister. Wiley-Liss, Inc., New York. 1995. x + 304 pp. 16 × 23.5 cm. ISBN 0-471-56173-8. $75.00. R. Ian Fryer [Full Article - PDF]

2278-2278

Physicians' Desk Reference. 50th Edition Medical Consultant: Ronald Arky. Medical Economics Co., Montvale, NJ. 1996. vi + 2879 pp. 23 × 28 cm. ISBN 1-56363-152-0. $69.95. Staff [Full Article - PDF]

2278-2278

PDR Generics. 1995. First Edition Medical Consultant: Ronald Arky. Medical Economics Data Production Co., Montvale, NJ. 1995. cxx + 2991 pp. 23 × 28 cm. ISBN 1-56363-118-0. $69.95. Staff [Full Article - PDF]

2278-2279

Reviews in Computational Chemistry. Volume 6. Edited by Kenny B. Lipkowitz and Donald B. Boyd. VCH Publishers, Inc., New York. 1995. xix + 480 pp. 16 × 24 cm. ISBN 1-56081-667-8. $90.00. Mark G. Bures [Full Article - PDF]

2279-2279

Stereoselective Synthesis Robert S. Atkinson. John Wiley and Sons Ltd., Chichester, England. 1995. xii + 529 pp. 15 × 23 cm. ISBN 0-471-95419-5. $59.95 (pbk). Gregory S. Hamilton [Full Article - PDF]

2280-2280

A Priori Prediction of Activity for HIV-1 Protease Inhibitors Employing Energy Minimization in the Active Site M. Katharine Holloway, Jenny M. Wai, Thomas A. Halgren, Paula M. D. Fitzgerald, Joseph P. Vacca, Bruce D. Dorsey, Rhonda B. Levin, Wayne J. Thompson, L. Jenny Chen, S. Jane deSolms, Neil Gaffin, Arun K. Ghosh, Elizabeth A. Giuliani, Samuel L. Graham, James P. Guare, Randall W. Hungate, Terry A. Lyle, William M. Sanders, Thomas J. Tucker, Mark Wiggins, Catherine M. Wiscount, Otto W. Woltersdorf, Steven D. Young, Paul L. Darke, and Joan A. Zugay [Full Article - PDF]